Laboratory

5 Dec. 2011


 

In case of no treatment, the H. Pilory once colonized in the tunica mucosae of stomach might exists in whole life of patient in spite the fact that patient already has immune response to it. However, it is well known that H. Pilory might be eliminated totally in elderly people and people who suffer from gastritis. It happens because of atrophic processes on tunica mucosae and H. Pilory does not find this medium the productive one productive for growing up. It is not known how many percentages of acute H. Pilory might to be transferred to chronic persisting form; however, the investigations show in some cases the spontaneous healing took place (spontaneous elimination of causative agent).

Diagnostics is conducted via asking questions of the patient whether the patient has dyspeptic complaints and symptoms, afterward conducting tests which can confirm or disprove H. Pilory presence in the organism.

Noninvasive (endoscopy is not required) tests include measuring of antibody titer to H.pylori antigens, measuring H. Pylori antigens in feces, and urease breathing test when patient drinks the solution marked with carbonium of ureaza which is getting split by bacteria and formation of dioxide carbon. The latter one is measured in outbreathing air due to mass-spectrometry.

Also, another ureaza tests are available for measuring of ammonia concentration in outbreating air. The main trustable reference method of H. Pilory diagnostic is biopcy, which is conducted during gastroduodenoscopy. The tissue taken during biopsy is being tested whether it has urease on it and H. Pilory antigens. Afterward it is being exposed to histological examination and cultural examination with discharging of H. Pilory on artificial nourishing medium.

Unfortunately, almost all diagnostic methods of H. Pilory have bias. Particularly, the results of biopsy depend on which part of stomach the material was taken. Therefore, it is important to take biopsy material from different part of stomach. Tests of measuring the antibodies to H. Pilory antigens have sensitivity from 76% to 84%. Some enzymes might influence on the activity of urease which is produced by H. Pilory. Therefore, the examination of urease activity might have psevdonegative results.

The H. Pilory might have some symptoms or does not have any symptoms at all (without any symptoms from patient side. It is considered that 70% of population has asymptotic course and it is proved that 2/3 of population is infected with H. Pilory which makes this infection the most spread in the world. The frequency to get infected with H. Pilory in developed countries is for 25% more than in developing countries and post Soviet countries. The H. Pilory has been met in teenagers because of low sanitary hygienic conditions. In the States and in Europe H. Pilory is widely spread among elderly people older than 60 years and among people from poor social-economic conditions.